The Real Economy: Manufacturing Jobs


Today’s jobs report was a strong one, and encouraging in its broad-based gains. Manufacturing is now up by more than 50,000 jobs since February. Combine that with the increase in job openings and total manufacturing labor demand over the period is up by more than 200,000 jobs. Not bad.

The Federal Reserve’s latest Beige Book reports: “Healthy labor demand was seen most frequently in manufacturing, construction, and some service sectors… Significant wage increases were most often connected to demand for skilled workers in construction and manufacturing.” Also encouraging.

And the Purchasing Managers’ Indices continue to report strong growth this month.

  • From S&P: “The headline seasonally adjusted S&P Global US Manufacturing Purchasing Managers’ Index™ (PMI®) was unchanged at 53.9 in August, signaling a solid expansion in the manufacturing economy. Output volumes rose for the fifteenth consecutive month…”

And from the Dallas Federal Reserve, Texas Manufacturing Activity Accelerates as Outlooks Improve Further.

Caveat: There may be something wrong with these numbers. The true experts in the free trade gang were so reliable about posting data from these sources in the months after Liberation Day, when it didn’t immediately turn positive. But now they’ve gone quiet. They may know something we don’t. We are monitoring the situation.

YOUR ONE WEEKEND READ is Why the World Needs to Force China’s Yuan to Revalue: A currency accord, enforced with tariffs, might be the only way to get China to act, from Greg Ip in the Wall Street Journal:

China’s massive and growing trade surplus threatens to hollow out its trading partners’ industrial bases. For years, the rest of the world has pleaded with China to change its economic model to rely more on domestic demand, and less on exports, to no avail.

A currency accord, enforced with tariffs, might be the only way to get China to act. The time may be ripe. Frustration with China is boiling over, especially in Europe. “This Chinese surge now threatens…the very core of Europe’s productive system,” a French government report said in February. In June, German Chancellor Friedrich Merz called for a new Plaza Accord aimed at China.

A meeting by central bank governors and finance ministers from the top 20 economies starting this weekend in Asheville, N.C., would be a good place to start the conversation.

Read the whole thing and, while you do, imagine former Trump CEA Chair Steven Miran bursting through the wall like the Kool-Aid Man. Did someone say a currency accord backed by tariffs?

Seriously, though, it’s good to see the international economic framework that has guided the Trump administration get the credit it deserves in the Journal…

…and with our trading partners! On Sunday, reported Reuters, G20 countries should consider more trade barriers on China to cut imbalances, Bessent says. “U.S. Treasury Secretary Scott Bessent said on Sunday he will encourage G20 members to re-examine terms of trade with China to shrink global imbalances and press Beijing to rebalance its economy away from exports and toward domestic consumption.”

On Tuesday, the U.S. released a “chair statement” from the summit with support from 19 of 20 countries. Any guess on who the one is? (The Financial Times provides a hint: China derails consensus after US-hosted G20.) As Bloomberg’s chief U.S. economist Anna Wong notes, “The 19-1 vote is really telling. Now that Europe is experiencing what the U.S. had experienced in the 2000s, there is finally something approaching moving toward a global consensus on global imbalances.”

Strange, that. We were warned by the very best experts that aggressive U.S. action on trade was going to alienate allies and drive them toward China. But it seems to have had the opposite effect, and now everyone is coming together to confront and isolate China.

From the Wall Street Journal: U.S. Says It’s Fed Up With China’s Overcapacity—and More Countries Agree. For instance, “When it comes to China, ‘everyone’s feelings have crossed a threshold,” said Japanese Finance Minister Satsuki Katayama.’” And, “a February report by the French government titled ‘The Chinese Steamroller’ said China’s export surge threatened the ‘very core of Europe’s productive system.’ In Indonesia, one of the poorest G-20 members, government officials have said that a flood of Chinese imports is hurting domestic industry.”

Indeed, it appears that by refusing to continue absorbing the brunt of the global imbalances itself, the U.S. has forced its partners to acknowledge and address the problem alongside it.

In his latest at Foreign Affairs, A Great Rebalancing Is Coming: Who Will Bear the Costs of a Global Trade Adjustment?, Michael Pettis looks at how all this might play out:

Beijing seems set on trying to preserve its surpluses for as long as possible. Washington is just as intent on reducing its deficits. If Europe can develop the political capacity to do the same, the burden of adjustment will increasingly fall onto the surplus economies, which would have to rely more on domestic demand and less on exports. If it cannot, Europe will absorb more and more of the global surpluses, and what appears today to be a trade conflict mainly between China and the United States may become a conflict between China and Europe—and a struggle between the two of them to avoid bearing steeper costs down the road.

If I were Canada, I’d work on teaming up with the United States against China on this one, rather than cozying up to China or thinking about joining the EU. I would not recommend the current strategy. As Secretary Bessent suggests, “I don’t think you can be in a tit-for-tat with someone who’s 13 times larger than you are.”

MORE GOOD READS FROM THE WEEK

I still don’t have the greenlight to emulate Matt Walsh’s “What Is a Woman?” documentary, sporting a man-bun wig while wandering around conferences to ask pretentious and underachieving economists “what is an economist?” So you’ll have to make do with this not-a-parody column from Soumaya Keynes in the Financial Times: When Is an Economist Not an Economist?

Think of economists as a guild whose members police who is allowed to join and what counts as true economics. By guarding the definition of economic expertise, they preserve their influence over the public and public policy.

This seems mostly right, with the caveat that their definition of “true economics” has fallen so flat on its face that defining their profession by its terms is at this point reducing their influence rather than preserving it. (Also, fun fact: Yes, Ms. Keynes is related to that Keynes! She is his great-great-niece.)

Forthcoming in the American Economic Review, from Daron Acemoglu et al: Eclipse of Rent-Sharing: The Effects of Managers’ Business Education on Wages and the Labor Share in the US and Denmark. Apparently, CEOs with business degrees don’t just wear snazzier quarter-zip fleeces, they also reduce wages by placing higher priority on shareholder value. They do not, on the other hand, increase output, investment, or employment growth.

And, from the New York Times, Wispr Flow is supposed to make writing effortless and magical. So I “wrote” this column with it. Amy X. Wang observes:

To tell you the truth, I hate this. I hate Wispr Flow so much. I hate that so many people in the world are lauding this like it’s the greatest invention, when actually I think it’s making everyone sound a little like an idiot, and now everybody has to read everyone else’s idiot words. I wish I could describe elegantly how much I hate it with some kind of handy, clever metaphor, but that kind of creativity comes to me through writing with my hands.

Speaking of things AI is ruining…

EDUCATION

NYC school system to ban AI for elementary, middle school students (Politico). Good for them. EPPC’s Patrick Brown makes the salient political point: “One political side has its leaders pushing robots as tutors and ‘A1 in every classroom.’ The other side has a major city administration keeping generative AI out of elementary and middle school classrooms. One of those paths is more family- and human-friendly than the other.”

  • This misstep by at least one faction of the right-of-center parallels the one I wrote about in Vice President Donald Trump: “If Trump brands Republicans as the party of liberty-means-license and ‘kids want to spend their time gambling with borrowed money because that’s their welfare-maximizing revealed preference,’ while Democrats become the party that speaks in moral terms and works to ensure young men build decent lives, the electoral consequences will be steep.”

In better news, from the State Department, “Vice President J.D. Vance and Secretary Marco Rubio announced today the launch of Foundry School, a training program for entrepreneurs, engineers, technicians, and industrial leaders to rebuild American manufacturing.” Cutting the enormous and counterproductive subsidies to traditional higher education is important, having new models like this toward which funding can be directed is equally important.

And back to worse news, from the Department of Justice, Ohio State University Agrees to $2.1M Settlement to Resolve Allegations that it Failed to Disclose Employees’ Ties to the People’s Republic of China in Applications for Federal Research Funding. Well the fine is good news, but as FDD’s Craig Singleton goes deeper on the problem in Higher Ed’s Secret Foreign Funding:

Washington has a list of names. What’s delaying disclosure? (Wall Street Journal).

China, China, China. It’s enough to make you think entangling our economy and society with a communist, authoritarian one might not be a good idea! Which brings us too…

Share

CHINA

A few decoupling items to keep an eye on, all from Bloomberg:

Top Automakers Urge Congress to Permanently Ban Chinese Cars: “The call by the US auto industry’s biggest trade association — echoing a similar plea made by the alliance and other auto groups in March — underscores mounting concerns in the domestic industry about the threat posed by China’s automobile makers. The alliance represents domestic carmakers including General Motors Co. as well as overseas giants Toyota Motor Corp. and Volkswagen AG.”

  • A wild, related statistic from BYD’s latest financial report: “First-half sales from overseas rose 34% to 181.3 billion yuan ($27 billion), accounting for 53% of the total, while they shrank 31% in Greater China.” That’s, um, not normal. “The results show how the vast Chinese market, where annual vehicle sales outnumber those of the US by nearly two-to-one, has become so brutal that not even its national champion can count on making money there. That’s why Chinese carmakers have increasingly turned abroad…”

Why the FCC Is Becoming America’s China Uber-Hawk: “Perhaps less-well recognized is that the regulator is emerging as a key instrument in Washington’s efforts to ‘de-risk,’ or in some cases outright decouple, US supply chains from China. This shouldn’t come as a surprise: Since before the FCC’s creation, the US national security apparatus (and especially the Navy) was paying close attention to devices that transmit and receive signals over the air.”

LABOR x IMMIGRATION

Don’t look now, but: Record-High 47% Want Unions to Have More Influence (Gallup). Of particular note, “partisans differ on whether unions should gain influence, but majorities in all three groups approve of unions overall: 89% of Democrats, 70% of independents and 52% of Republicans. Broad Democratic approval is typical, but this is only the second time in the past quarter century — the first being in 2022 — that a majority of Republicans have approved of unions.”

Perhaps not unrelatedly, the quiet withdrawal of the case for mass immigration continues apace, even on the Wall Street Journal opinion page. In Immigration Becomes a Global Powder Keg, Walter Russell Mead makes the obvious yet not so frequently made point: “In recent years, American immigration advocates have argued that falling birthrates create a need for more immigrant labor. Those arguments are less convincing in the face of the accelerated automation that artificial intelligence appears ready to unleash.”

Example? Watch this “AgTech moon landing moment.” The first robotically harvested head of lettuce!

Perhaps not unrelatedly, the Center for Immigration Studies has released its latest analysis on the foreign-born population in the United States, finding that since January 2025, “The total foreign-born population declined 2.9m; Illegal immigrant population may have declined 2.3m.”

Either “root causes” like climate change suddenly reversed their effect, or enforcing the law works. You be the judge.

One place that enforcing the law seems to work is trucking. The U.S. Department of Transportation announced that it has shut down more than 100 commercial driver’s license (CDL) schools that were granting licenses to drivers who failed English proficiency tests, among a variety of actions. Vice President JD Vance on the problem: “We know that trucking is one of the best sources of employment for non-college-educated men. It was bad for people’s jobs, but it also made our streets and our highways a lot less safe.”

OPT, Yeah You Know Me (you’re welcome, Gen X). Here’s a problem that deserves more attention and seems easy enough to solve: alongside the H-1B mess, people are catching on to the absurdities of Optional Practical Training program (OPT), which was intended to allow foreign college students to work temporarily, but has been expanded by corporations and allied regulators into yet another boondoggle. Bloomberg actually had one of the best rundowns on this a number of years ago in The STEM Graduate System Is Broken. Here’s How to Fix It:

OPT has also opened a side door into the U.S. job market with minimal labor protections and oversight. It is increasingly funneling cheaper and more pliable, visa-dependent foreign candidates into fields such as software engineering and development, depressing wages and making a once-attractive career path less desirable. Moreover, even as OPT benefits U.S. schools eager to attract foreign students, it can undercut American students looking for work. And there have been too many instances of exploitation and outright fraud.

Fair warning, though, from the Cato Institute, which is proudly promoting testimony from its director of immigration studies, David Bier: “If you make legal immigration impossible, don’t complain about illegal immigration. You created it. You made it illegal.” That’s one way of looking at it! Fortunately, not one that conservatives have to put up with any longer.

And finally, speaking of things conservatives don’t have to put up with any longer…

YOUR BAD TWEET OF THE WEEK

Likely a regular feature, given the volume of foolishness out there (nominations welcome). Our inaugural edition comes to us from Grover Norquist’s former tax policy director, Ryan Ellis:

X avatar for @RyanLEllis

Ryan Ellis@RyanLEllis

@PhilWMagness They have no interest in reducing government spending. At all.

Which is kind of the whole point of being a conservative.

4:58 PM · Sep 2, 2026 · 4.63K Views

4 Replies · 10 Reposts · 47 Likes

Enjoy the weekend!

Leave a comment

Free Training

Source link

Foundry School Launched To Rebuild American Manufacturing


The Trump administration has launched a Foundry School, a training program for entrepreneurs, engineers, technicians, and industrial leaders to rebuild American manufacturing.

The launch of the training school was announced by Vice President J.D. Vance and Secretary of State Marco Rubio at an event held at the Donald J. Trump Institute of Peace.

They were joined by Under Secretary for Economic Affairs Jacob Helberg, presidents and senior leaders from the eight universities working to deliver the Foundry School curriculum and chief executives and company presidents from manufacturing and technology companies.

It is estimated that American manufacturers will need 3.8 million skilled workers by 2033 in semiconductors, defense, energy, and beyond. The State Department, working with Congress, plans to support the participation of Pax Silica economies in Foundry School and is working with Stanford University to develop the curriculum for U.S. and foreign participants. Foundry School will collaborate with Pax Silica economies to create opportunities for America and partners in industries critical to our nation’s economic security.

Foundry School is anchored in a first-of-its-kind advanced manufacturing curriculum developed by Stanford University that also features keystone lectures provided by seven universities. Stanford University has collaborated with Arizona State University, Georgia Institute of Technology, The Ohio State University, The Pennsylvania State University, the University of Kansas, Vanderbilt University, and Washington University in St. Louis. Across these eight campuses, the program will run 17 sessions, each taught by founders and CEOs from advanced manufacturing enterprises.

These industry leaders will be drawn from the United States and Pax Silica participants, including South Korea, Japan, Taiwan, and India, covering everything it takes to build and run a world-class manufacturing enterprise.

Foundry School is a flagship initiative of Pax Silica, the Trump Administration’s economic security partnership connecting governments, industry, and universities to strengthen the critical supply chains and industrial capabilities that underpin the AI economy. Foundry School connects students and workers directly with the companies building and operating advanced manufacturing facilities.

For comments and feedback contact: editorial@rttnews.com

Business News

Free Training

Source link

Sen. Gallego tours Chandler manufacturer, talks U.S. manufacturing


CHANDLER, AZ — Inside a southwest Chandler industrial park is Isola, a company that manufactures parts for circuit boards.

The company was recently acquired by Principal Minerals, which is focused on rebuilding what it calls the “missing midstream,” essentially the processing gap in U.S. manufacturing.

Sen. Ruben Gallego toured the plant Thursday, one of a few stops in Chandler. He said his goal for the trip was to see the process behind Arizona-based companies and understand how the government can help.

“Supporting these American companies, making sure these American companies stay in American hands, that they are going to be innovative but can be able to grow, are also very important not just to our economy but to our national security,” Gallego said.

Companies like Isola develop materials that go into various electronics and technology, including data centers.

Gallego said data centers need to be regulated.

“They can’t just go where ever they want, they can’t be drawing energy and costing other people, they can’t be you know sucking up water, and certainly a lot of our communities need to have a say where they are,” Gallego said.

He believes the data center fight will eventually be resolved through regulations or by stopping some projects outright.

But he said the longer-term focus should be on what companies like Isola are doing, bringing manufacturing back to the U.S.

“The long term fight that we really need in this country to make sure we continue to bring high value manufacturing back to the United States that pays well and that is important to our national security,” Gallego said.

This story was reported on-air by a journalist and has been converted to this platform with the assistance of AI. Our editorial team verifies all reporting on all platforms for fairness and accuracy.

Null

We’re all about Chandler — the schools, the neighborhoods, the businesses, the decisions being made at City Hall and in the community that affect your daily life.

Connect with your community by joining the Your Chandler News Facebook Group!

Your Latest Chandler News:

Free Training

Source link

US-Canada trade war tests deep manufacturing ties between Detroit and Windsor


VITAL CROSS-BORDER SUPPLY CHAINS

Detroit remains one of the centres of North America’s automotive industry, with the region producing more than 1.7 million vehicles a year.

Many of the parts and materials used in those vehicles come from Canada.

The Canada Border Services Agency describes Windsor-Detroit as the country’s most important trade corridor, carrying about 30 per cent of Canada-US trade by truck.

One Detroit aluminium supplier, which asked not to be named, said the trade dispute was making it more difficult to do business across the border.

The company has been supplying manufacturers for more than 75 years.

“We’ve always had a good relationship with a lot of Canadian aluminium mills. And it’s becoming more difficult from a price point to work with them,” a representative told CNA.

Its biggest concern is what happens if tariffs make it increasingly difficult to source the materials it needs.

“Best-case scenario, I would say, we go back to the good old days. We forget any of this ever happened,” the representative added.

“Worst-case scenario is everything dries up. Eventually, it might come to the point where we cannot source a lot of our material that we rely on.”

Free Training

Source link

Telit Cinterion to Onshore its Trusted Manufacturing to the United States


The largest western IoT player to onshore manufacturing of cellular modules and products in the U.S. with production starting in October 2026

  • Pennsylvania facility: New manufacturing facility in the heart of the nation’s largest defense industrial complex establishes domestic production capacity to support critical infrastructure customers, advances America’s technology manufacturing base, and creates local jobs.
  • Location is key: Pennsylvania supports Telit Cinterion’s position as the leading IoT module vendor to critical national infrastructure, defense and mission critical applications globally.
  • First in industry: Telit Cinterion is bringing its pioneering trusted and secure technology, developed over 30 years in the U.S. and allied nations, to be manufactured domestically.

BOCA RATON, Fla., Sept. 2, 2026 /PRNewswire/ — Telit Cinterion, a global Internet of Things (IoT) enabler, today announced that it is expanding its global manufacturing apparatus by adding operations in the United States. From the new facility in Bristol, Pennsylvania, starting in October 2026, Telit Cinterion will serve the American and global markets with cellular 4G and 5G IoT modules, and OEM customer products such as routers and gateways.

The 8,000 square-foot facility will house manufacturing, testing, and quality assurance. Support functions including engineering and supply chain will be supported by the company’s existing offices in Research Triangle Park, North Carolina, and Boca Raton, Florida. The first phase of the initiative is expected to create at least 50 high-value jobs.

The start of U.S. production marks the first phase of Telit Cinterion’s long-term commitment to expanding domestic capabilities. The new operation establishes a foundation for continued investment in U.S. manufacturing, workforce development, and supply chain resiliency.

“The Bristol facility represents an important step in strengthening trusted technology supply chains and increasing domestic manufacturing capacity for IoT connected devices and AI-enabled solutions,” said Paolo Dal Pino, Telit Cinterion CEO. “It on shores our trusted manufacturing capability designed to provide U.S. and global customers with, greater traceability, quality assurance, operational resilience, and greater supply chain transparency that aligns with new regulations in the U.S. and western countries.”
 

More information about Telit Cinterion U.S. manufacturing may be found here. 

About Telit Cinterion

Telit Cinterion is a global IoT leader with over 30 years of innovation experience. It provides modules, connectivity plans and services, platforms, and secure, scalable custom solutions.

Telit Cinterion’s product portfolio supports mission-critical applications across industries. In addition, it simplifies lifecycle management and device-to-cloud security. The company helps enterprises connect, manage and grow their IoT systems with confidence.

OEMs, system integrators and service providers worldwide trust Telit Cinterion. The company drives digital transformation and unlocks the power of connected technology.

For more information, follow us on YouTube, X, LinkedIn and Facebook. Visit telit.com or subscribe to receive our marketing communications.

Copyright © 2026 Telit IoT Solutions Holding Ltd. and/or its affiliated companies. All rights reserved. Telit Cinterion, Telit, OneEdge, Cinterion, and all associated logos are trademarks and/or registered trademarks of Telit Communications S.p.A, Telit Communications LTD, Telit IoT Solutions Holding Ltd. and/or their affiliated companies in the United States and/or other countries. Other names used herein may be trademarks of their respective owners.

Media Contacts

Greg Oppenheim
Telit Cinterion
+1 949-540-1278
Greg.Oppenheim@telit.com

Casey Bush
GRC for Telit Cinterion
telit@globalresultspr.com

View original content to download multimedia:https://www.prnewswire.com/news-releases/telit-cinterion-to-onshore-its-trusted-manufacturing-to-the-united-states-302868058.html

SOURCE Telit Cinterion

Free Training

Source link

Telit Cinterion to Onshore its Trusted Manufacturing to the United States


The largest western IoT player to onshore manufacturing of cellular modules and products in the U.S. with production starting in October 2026

  • Pennsylvania facility: New manufacturing facility in the heart of the nation’s largest defense industrial complex establishes domestic production capacity to support critical infrastructure customers, advances America’s technology manufacturing base, and creates local jobs.
  • Location is key: Pennsylvania supports Telit Cinterion’s position as the leading IoT module vendor to critical national infrastructure, defense and mission critical applications globally.
  • First in industry: Telit Cinterion is bringing its pioneering trusted and secure technology, developed over 30 years in the U.S. and allied nations, to be manufactured domestically.

BOCA RATON, Fla., Sept. 2, 2026 /PRNewswire/ — Telit Cinterion, a global Internet of Things (IoT) enabler, today announced that it is expanding its global manufacturing apparatus by adding operations in the United States. From the new facility in Bristol, Pennsylvania, starting in October 2026, Telit Cinterion will serve the American and global markets with cellular 4G and 5G IoT modules, and OEM customer products such as routers and gateways.

The 8,000 square-foot facility will house manufacturing, testing, and quality assurance. Support functions including engineering and supply chain will be supported by the company’s existing offices in Research Triangle Park, North Carolina, and Boca Raton, Florida. The first phase of the initiative is expected to create at least 50 high-value jobs.

The start of U.S. production marks the first phase of Telit Cinterion’s long-term commitment to expanding domestic capabilities. The new operation establishes a foundation for continued investment in U.S. manufacturing, workforce development, and supply chain resiliency.

“The Bristol facility represents an important step in strengthening trusted technology supply chains and increasing domestic manufacturing capacity for IoT connected devices and AI-enabled solutions,” said Paolo Dal Pino, Telit Cinterion CEO. “It on shores our trusted manufacturing capability designed to provide U.S. and global customers with, greater traceability, quality assurance, operational resilience, and greater supply chain transparency that aligns with new regulations in the U.S. and western countries.”
 

More information about Telit Cinterion U.S. manufacturing may be found here. 

About Telit Cinterion

Telit Cinterion is a global IoT leader with over 30 years of innovation experience. It provides modules, connectivity plans and services, platforms, and secure, scalable custom solutions.

Telit Cinterion’s product portfolio supports mission-critical applications across industries. In addition, it simplifies lifecycle management and device-to-cloud security. The company helps enterprises connect, manage and grow their IoT systems with confidence.

OEMs, system integrators and service providers worldwide trust Telit Cinterion. The company drives digital transformation and unlocks the power of connected technology.

For more information, follow us on YouTube, X, LinkedIn and Facebook. Visit telit.com or subscribe to receive our marketing communications.

Copyright © 2026 Telit IoT Solutions Holding Ltd. and/or its affiliated companies. All rights reserved. Telit Cinterion, Telit, OneEdge, Cinterion, and all associated logos are trademarks and/or registered trademarks of Telit Communications S.p.A, Telit Communications LTD, Telit IoT Solutions Holding Ltd. and/or their affiliated companies in the United States and/or other countries. Other names used herein may be trademarks of their respective owners.

Media Contacts

Greg Oppenheim
Telit Cinterion
+1 949-540-1278
[email protected]

Casey Bush
GRC for Telit Cinterion
[email protected]

SOURCE Telit Cinterion

Free Training

Source link

Shionogi gains $36.9 million U.S. order for Fetroja


KEY POINTS

  • Shionogi secures $36.9 million after U.S. government exercises cefiderocol procurement option
  • BARDA Project BioShield contract includes options for U.S. manufacturing, pathogen-focused development and pediatric label expansion
  • Initial funding totals $119 million, with potential contract value rising to $482 million

Shionogi gains $36.9 million U.S. order for Fetroja

The BARDA Project BioShield contract also covers U.S. manufacturing, priority-pathogen development and potential pediatric label expansion for cefiderocol. Photo by Pavel Danilyuk on Pexels
Pavel Danilyuk

Shionogi & Co. said on August 28 that the U.S. government had exercised a procurement option for cefiderocol, a treatment for Gram-negative bacterial infections, under a contract through the Biomedical Advanced Research and Development Authority’s Project BioShield program.

The exercised option will bring $36.9 million to the Shionogi group. Cefiderocol is sold in the United States under the brand name Fetroja.

Shionogi signed the contract with the U.S. government on April 8 as part of Project BioShield, a U.S. Department of Health and Human Services program designed to accelerate the research, development, procurement and supply of medical countermeasures against chemical, biological, radiological and nuclear threats.

Under the agreement, Shionogi initially received $119 million in funding. The contract includes multiple related options, including the establishment of a U.S. pharmaceutical manufacturing site for cefiderocol, development targeting infections caused by high-priority pathogens considered biological threats, and a supplemental new drug application to the U.S. Food and Drug Administration to expand the drug’s label for hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia in pediatric patients.

If those options advance, total funding under the contract could reach as much as $482 million, the company said.

Shionogi said the impact of the procurement option on its consolidated earnings for the fiscal year ending March 2027 would be minimal.

Cefiderocol is marketed in the United States for adult patients with complicated urinary tract infections, including pyelonephritis, caused by certain Gram-negative bacteria, as well as hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia. The drug is also sold in multiple markets including Japan, Europe and Taiwan.

Shionogi is also working with the Global Antibiotic Research and Development Partnership and the Clinton Health Access Initiative to prepare for broader patient access to cefiderocol in low- and middle-income countries and upper-middle-income countries, the company said. Antimicrobial resistance is a major public health concern globally, and the company said an estimated 1.14 million people died worldwide in 2021 from AMR.

Free Training

Source link

ISM Manufacturing PMI August 2026: Expansion Slows Amid Tariff and War Concerns – News and Statistics


Sep 1, 2026

The U.S. manufacturing sector continued its expansion in August, marking the eighth straight month of growth, as the Institute for Supply Management‘s latest Purchasing Managers Index came in at 54.6%—a decline of one full percentage point from July’s figure. ISM also reported that the broader economy has now grown for 22 consecutive months. Any reading below the 50% threshold signals contraction within the industry.

Meanwhile, the S&P Global U.S. Manufacturing PMI held steady at 53.9%, matching its July level. Susan Spence, chair of ISM’s Manufacturing Business Survey Committee, said during a Monday media call that despite the ongoing expansion, the Iran war and tariff threats remain the foremost concerns for the manufacturing sector.

Survey comments in August were split, with 42% positive and 58% negative, translating to a 1-to-1.4 ratio of positive to negative sentiment, according to Spence’s news release. Among the negative remarks, pricing volatility was cited in 57%, extended lead times in 46%, the Iran war in 30%, and tariffs in 29%.

Five of the six largest manufacturing industries saw growth in August: transportation equipment, petroleum and coal products, machinery, computer and electronic products, and food, beverage and tobacco products.

The New Orders Index rose for the eighth consecutive month, registering 53.7%—a drop of 3 percentage points from July’s 56.7%. The Production Index came in at 58.3%, slightly lower by 0.2 percentage point compared to July’s 58.5%. The Prices Index stayed in expansion territory at 71.1%, unchanged from the prior month. The Backlog of Orders Index fell to 51.8%, down 3.2 percentage points from July’s 55%. The Employment Index slipped to 51.2%, a 1.6-percentage-point decrease from July’s 52.8%, with the sector adding 5,000 jobs in July.

The Supplier Deliveries Index pointed to slower performance for the ninth month in a row, following a single month in faster territory. It registered 59.3%, up 0.4 percentage point from July’s 58.9%. This is the only ISM PMI Report index where a reading above 50% denotes slower deliveries. The Inventories Index stood at 50.6%, down 0.6 percentage point from July’s 51.2%. The Customers Inventories Index climbed to 42.8%, a 2.1-percentage-point increase from the 40.7% recorded in July. The New Export Orders Index edged up 0.2 percentage point to 53.2%, compared to 53% the previous month. The Imports Index fell to 52.5%, a 3.2-percentage-point decline from July’s 55.7%.

Among ISM’s four demand indicators, three—New Orders, Backlog of Orders, and New Export Orders—remained in expansion, while the Customers Inventories Index stayed in too low territory, contracting at a faster pace. A too low reading on the Customers Inventories Index is typically viewed as a positive sign for future production.

Spence noted that August manufacturing activity stayed in expansion, though it lost ground in several key metrics, particularly New Orders, Backlog, and Imports. Of the five subindexes feeding into the PMI, only Supplier Deliveries accelerated compared to the prior month, signaling a continued slowdown in the supply chain.

Numerous respondents pointed to tariffs, inflation, and supply chain disruptions as drags on their operations. One respondent from the chemical products industry lamented that the economy was interfering with otherwise strong business, citing price escalations from tariffs and the Strait of Hormuz conflict as threats to sales and customer purchasing power. A respondent in the computer and electronic products sector described a fresh supply chain crisis, more severe and complex than the one seen during and after COVID-19, driven by AI infrastructure demands and global market volatility tied to the Middle East war and shifting trade regulations. The steel industry has also felt the impact, most recently from 50% tariffs imposed by Canada that mirrored new U.S. tariffs.

Spence expressed less optimism about this month’s results compared to last month’s. She highlighted that this was the first time she had observed a drop exceeding three points in three significant areas. While demand sentiment remains broadly positive, it has weakened, and she voiced uncertainty about customer behavior, indicating she is beginning to see warning signs.

Free Training

Source link

Palm Trees to Seaweed: Boosting U.S. Manufacturing


Mingyu Qiao will use an anaerobic digestion process to transform seaweed into a sustainable replacement for palm oil

Palm oil and palm kernel oil are versatile oleochemical feedstocks widely used in food and personal care products and can be converted into industrial products such as biolubricants and bio-based plasticizers.

Despite its ubiquity, though, there are serious problems with palm oil. Palm oil production has led to deforestation and biodiversity loss, as well as unjust labor practices in Southeast Asia, where the majority of the world’s palm oil supply is produced.

Because it is derived from a tropical plant, the United States currently relies on imports to meet 100% of its demand for this critical platform chemical across the food, cosmetics, industrial lubricants, and plasticizer sectors creating significant supply chain vulnerabilities.

Mingyu Qiao, assistant professor of innovation and entrepreneurship in the Department of Nutritional Sciences (CAHNR), has received a $1.875 million grant from the Department of Energy’s Alternative Fuels and Feedstocks Office to turn seaweed into a replacement for palm oil and other medium-chain fatty acids (MCFAs) like coconut oil.

Seaweed farming has already established a foothold in Connecticut and New England as a sustainable and easy-to-grow crop.

Not only doesn’t seaweed consume fertilizers, water, or pesticides, as other crops do, but it also acts as a natural filter to clean the water in which it grows. Seaweed can be produced rapidly and on a large scale without competing for space with land-based crops.

“With seaweed, you can just put it in the ocean, and it’ll grow itself,” Qiao says. “You don’t need to apply any pesticides or fertilizers because the ocean has all the nutrients it needs.”

Qiao is using sugar kelp, a popular edible seaweed that is native to and already produced in Connecticut’s waters, for his research.

A man sits in a chair next to a desk wearing a UConn jacket.Mingyu Qiao poses for a photo in his office in the Advanced Technology Laboratory (ATL). (Jason Sheldon/UConn Photo)

Qiao is using a biological process known as arrested anaerobic digestion to transform seaweed into MCFAs. Anaerobic digestion is a natural process through which bacteria break down organic matter in the absence of oxygen.

Normally this process produces methane, a potent greenhouse gas. However, the natural salinity of seaweed inhibits methane-producing microorganisms, redirecting the process toward volatile fatty acid production. These acids can then be separated and upgraded into medium-chain fatty acids (MCFAs), creating a more sustainable pathway.

This project is a collaboration with the Idaho National Laboratory, the recipient of $200,000 of the grant. The Laboratory will develop a method for preserving seaweed biomass long enough for it to be processed. Normally, seaweed rots within a few days of being out of the water. By adding lactic acid bacteria – the same bacteria found in yogurt – the researchers can stabilize and store the seaweed for months.

“That is the biggest problem for seaweed compared with something like corn or soybeans,” Qiao says. “This will solve that problem.”

Because the MCFAs Qiao’s team will produce are derived from seaweed, they can be used in all industries, like food and personal care, that require additives to be all-natural.

“For anything that comes into contact with the body, consumers increasingly prefer natural or bio-based materials because petroleum-derived products may contain trace impurities, some of which could pose toxicological or carcinogenic risks,” Qiao says.

This work will help support the U.S.’s supply chain resilience of critical chemicals and materials.

“For critical materials, [it’s important to be able to] produce them domestically,” Qiao says. “Even if it’s a little bit more expensive, those companies are willing to pay for that because it’s more secure. You can fully control that.”

This project is a collaboration between researchers in the College of Agriculture, Health and Natural Resources and the College of Engineering with co-PIs Baikun Li, professor in the Department of Civil & Environmental Engineering; Jeffrey McCutcheon and Xiao-Dong Zhou, professors, and Burcu Beykal, assistant professor, in the Department of Chemical & Biomolecular Engineering; and Bradley Wahlen, research scientist at Idaho National Laboratory. All UConn faculty are part of the Center for Clean Energy Engineering (C2E2).

Free Training

Source link

MFN Program Grows to 26 Drugmakers as Nine More Commit to $19.6B in US Manufacturing


President Donald J. Trump announced nine new Most-Favored-Nation (MFN) agreements with pharmaceutical manufacturers on August 31, bringing the program’s total roster to 26 companies. The administration says that group now accounts for 89% of the branded drug market,1 a milestone with direct implications for how supply chain and market access teams plan pricing, procurement, and Medicaid formulary strategy heading into 2027.

Nine more manufacturers sign on

The newly announced participants are a group of mid-sized manufacturers:

  • Alcon
  • Astellas Pharma
  • BeOne Medicines
  • BridgeBio
  • CSL
  • Kyowa Kirin
  • Sun Pharma
  • Teva Pharmaceuticals
  • UCB

The products affected span a wide swath of costly and chronic therapeutic areas, including hemophilia, Parkinson’s disease, macular degeneration, glaucoma, liver disease, dermatologic conditions, and multiple cancers.1 Under the deals, every state Medicaid program gains access to MFN pricing on these companies’ products, which the White House projects will translate into billions of dollars in aggregate savings.1 A companion White House fact sheet frames the agreements as closing off the ability of other countries to use price controls to benefit from American drug innovation without paying comparable prices.1

Manufacturing and supply chain commitments take center stage

For supply chain and commercialization leaders, the more consequential piece may be what’s attached to the pricing deals rather than the pricing itself. The nine companies have collectively pledged at least $19.6 billion in near-term U.S. manufacturing investment, and several are directing material toward the Strategic Active Pharmaceutical Ingredients Reserve, a stockpile meant to reduce dependence on foreign API sources and buffer against future supply disruptions.1

Individual contributions include:

  • UCB: 163 tons of levetiracetam, an anticonvulsant
  • Sun Pharma: 71.4 tons of clindamycin and 6.75 tons of doxycycline, both antibiotics
  • Teva Pharmaceuticals: 45 metric tons of metronidazole (antibiotic/antiprotozoal) and 4.8 tons of amlodipine (antihypertensive)
  • Astellas: 25 kg of tacrolimus, an immunosuppressant used in transplant care

For sourcing and procurement teams, these donations are worth tracking as an early signal of how manufacturers may reallocate API supply commitments going forward.

What it means for market access

The Medicaid provisions are the piece most relevant to market access and payer-strategy teams, though industry watchers caution the practical effect on patients may be limited. Lindsay Bealor Greenleaf, head of market access policy strategy at ADVI, told our sister publication Pharmaceutical Executive that Medicaid patients typically already pay only $4 to $8 out of pocket, and that the financial impact of the voluntary deals falls on manufacturers rather than patients. That distinction matters for commercialization planners weighing how MFN participation will affect net pricing and rebate structures rather than front-line patient access.

The road to 26 agreements

The nine deals build on momentum going back to May 2025, when the MFN executive order was signed, followed two months later by letters sent to 17 major manufacturers directing them to bring U.S. list prices in line with the lowest price charged in other developed markets.2 According to the White House, all 17 of those companies have since signed on.1 Combined with today’s additions, the MFN roster now includes Pfizer, AstraZeneca, EMD Serono, Eli Lilly, Novo Nordisk, Amgen, Bristol Myers Squibb, Boehringer Ingelheim, Genentech, Gilead Sciences, GSK, Merck, Novartis, Sanofi, Johnson & Johnson, AbbVie, Regeneron, Alcon, Astellas Pharma, BeOne Medicines, BridgeBio, CSL, Kyowa Kirin, Sun Pharma, Teva Pharmaceuticals, and UCB.1

What remains undone

Even with 26 manufacturers now committed, the administration is pushing Congress to pass the Great Healthcare Plan, broader legislation aimed at lowering drug prices and insurance premiums, increasing accountability for insurers, and expanding price transparency.3 Unlike the manufacturer-by-manufacturer MFN deals, that agenda depends on legislative action, meaning its outcome, and any further supply chain or market access implications, rests with lawmakers rather than executive negotiation.


References

1. Fact Sheet: President Donald J. Trump Announces Deal with Nine Additional Pharmaceutical Manufacturers to Lower Drug Prices for Americans, The White House, August 31, 2026. View source

2. White House to announce new drug pricing deals with biotechs, Bloomberg News reports, Reuters, August 26, 2026. View source

3. Fact Sheet: President Donald J. Trump Calls on Congress to Enact The Great Healthcare Plan, The White House, January 15, 2026. View source

Free Training

Source link